Anti-Cancer Molecules Predicted By Computer

A new computer-based method of analyzing cellular activity has correctly predicted the anti-tumour activity of several molecules. Research published in BioMed Central's open access journal Molecular Cancer describes 'CoMet' - a tool that studies the integrated machinery of the cell and predicts those components that will have an effect on cancer.



Jeffrey Skolnick, in collaboration with John McDonald, led a team from the Georgia Institute of Technology who have developed this new strategy. As Skolnick explains, "This opens up the possibility of novel therapeutics for cancer and develops our understanding of why such metabolites work. CoMet provides a deeper understanding of the molecular mechanisms of cancer".



The small molecules that are naturally produced in cells are called metabolites. Enzymes, the biological catalysts that produce and consume these metabolites are created according to a cell's genetic blueprints. Importantly, however, the metabolites can also affect the expression of genes. According to the authors "By comparing the gene expression levels of cancer cells relative to normal cells and converting that information into the enzymes that produce metabolites, CoMet predicts metabolites that have lower concentrations in cancer relative to normal cells".



The research proves that by adding such putatively depleted metabolites to cancer cells, they exhibit anticancer properties. In this case, growth of leukemia cells was slowed by all nine of the metabolites suggested by CoMet. The future for this treatment looks bright, in McDonald's words, "While we have only performed cell proliferation assays, it is reasonable to speculate that some metabolites may also exhibit many other anticancer properties. These could be important steps on the road to a cure".







Notes:



1. Identification of metabolites with anticancer properties by Computational Metabolomics

Adrian K Arakaki, Roman Mezencev, Nathan J Bowen, Ying Huang, John F McDonald and Jeffrey Skolnick

Molecular Cancer (in press)


Aarticle available at journal website: molecular-cancer/


All articles are available free of charge, according to BioMed Central's open access policy.



2. Molecular Cancer, a forum for exciting findings in the field of cancer-related research, is an Open Access journal, providing an unparalleled opportunity to present information to specialists and the public. The online appearance of Molecular Cancer allows the immediate publication of accepted articles and the presentation of large amounts of data and supplemental information.



3. BioMed Central (biomedcentral/) is an independent online publishing house committed to providing immediate access without charge to the peer-reviewed biological and medical research it publishes. This commitment is based on the view that open access to research is essential to the rapid and efficient communication of science.



Source: Charlotte Webber


BioMed Central


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